SIRT6 Puts Cancer Metabolism in the Driver’s Seat
نویسندگان
چکیده
The rewiring of metabolism in cancer is thought to result from hyperactivation of signaling pathways that instruct cells to grow. Sebastian et al. show that loss of the tumor suppressor SIRT6 transforms cells by activating tumor metabolism. This occurs independently of mutations in canonical growth signaling pathways and reveals a tumorigenic role for cancer metabolism.
منابع مشابه
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells. Importantly, loss of SIRT6 leads to tumor formation without activation of known oncogenes, whereas transfor...
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عنوان ژورنال:
- Cell
دوره 151 شماره
صفحات -
تاریخ انتشار 2012